Journal article
Cholinergic muscarinic M4 receptor gene polymorphisms: A potential risk factor and pharmacogenomic marker for schizophrenia
E Scarr, JY Um, TF Cowie, B Dean
Schizophrenia Research | ELSEVIER | Published : 2013
Abstract
Although schizophrenia is a widespread disorder of unknown aetiology, we have previously shown that muscarinic M4 receptor (CHRM4) expression is decreased in the hippocampus and caudate-putamen from subjects with the disorder, implicating the receptor in its pathophysiology. These findings led us to determine whether variation in the CHRM4 gene sequence was associated with an altered risk of schizophrenia by sequencing the CHRM4 gene from the brains of 76 people with the disorder and 74 people with no history of psychiatric disorders. In addition, because the CHRM4 is a potential target for antipsychotic drug development, we investigated whether variations in CHRM4 sequence were associated w..
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Grants
Awarded by MedStar Health Research Institute
Funding Acknowledgements
This work was supported by the National Medical & Health Research Council (project grants 509306 and 566967 to ES and BD; Senior Research Fellowship #APP1002240 to BD), the Australian Research Council (Future Fellowship FT100100689 to ES) and the Ministry of Public Administration and Security of Korea (Korean Government Fellowship No. 2008-E-0515 to JYU) as well as Operational Infrastructure Support (OIS) from the Victorian State Government. None of the funding sources played any role in the study design; collection, analysis or interpretation of data; in the writing of the report; or in the decision to submit the paper for publication.